Are telomeres really the key to living longer, youthful lives?

Are telomeres really the key to living longer, youthful lives?

Telomeres — the “caps” at the end of chromosomes that protect the DNA from damage — have been associated with greater longevity. In theory, longer telomeres should allow a cell to divide more times and therefore live longer. However, a new study has suggested that longer telomeres could increase a person’s risk of chronic health conditions. So are longer telomeres the key to longevity, or should we be looking for other ways of living longer, healthier lives?

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What do we really know about how telomere length relates to aging processes? Image credit: Lucas Ottone/Stocksy.

Increasing age is the greatest risk factor for many health conditions. However, some people seem to age better than others, enjoying an active, healthy existence long into old age. So how do they do this? Some credit a healthy lifestyle, others luck, and others genetics.

One theory about aging well lies in our chromosomes or, more specifically, our telomeres — the protective lengths of repetitive deoxyribonucleic acid (DNA) and protein found at the end of each chromosome.

Inside every cell in the human body there are 23 pairs of chromosomes. Each chromosome is made up of DNA wound around proteins. That DNA contains genes — inherited instructions for all the cell’s functions.

Telomeres are found in the terminal region of each chromosome and do not contain genes. Each time a cell divides, the chromosomes replicate and the telomeres shorten. This allows the cell to divide without losing vital genes. Eventually, the telomeres are too short for the cell to divide again and the cell becomes senescent or die.

Shorter telomeres have been associated with increased disease incidence and decreased survival times. Senescent cells no longer divide, but remain active and have been implicated in many diseases of agingsuch as osteoarthritis, atherosclerosis, and cancer.

Longer telomeres should mean that cells can divide more often before entering senescence or dying, therefore increasing longevity. animal studies have shown that telomeres shorten faster in short-lived animals than in longer-lived ones.

A study in mice bred to have hyper-long telomeres found that they were lean, had low cholesterol and LDL levels, and improved glucose and insulin tolerance. They also lived longer and had a lower incidence of cancer than regular mice.

So longer telomeres mean longer, healthier lives. Or do they?

Telomeres are maintained by the enzyme telomerase. This adds to the telomeres, preventing them from shortening as rapidly, thereby allowing the cells to live for longer. A good thing, perhaps, until we learn that cancer cells have increased amounts of telomerase, which allows them to continue dividing.

Sebnem Unluisler, genetic engineer and chief longevity officer at the London Regenerative Institute in the United Kingdom, told MedicalNewsToday:

“Studies have demonstrated a correlation between telomere length and biological age. Generally, shorter telomeres are associated with advanced chronological age and increased susceptibility to age-related diseases. Moreover, individuals with certain genetic variations or lifestyle factors that accelerate telomere shortening tend to exhibit a more rapid aging phenotype.”

Telomere length has been likened to a “biological clock,” with shorter telomeres indicative of greater biological age. Several lifestyle factors have been associated with shorter telomeres. One is a lack of physical activity.

In one study, sedentary women were found to have telomeres that indicated they were biologically 8 years older than women of the same chronological age who exercised more.

Tobacco smoking increases the risk of many diseases, and it also accelerates the shortening of telomeres. A study found that telomere shortening was enhanced in the circulating white blood cells of smokers, increasing the rate of biological aging.

getting insufficient sleep can also influence telomere length, shortening telomeres even in childhood, which may lead to impaired health.

All of these are linked to inflammation, which is associated not only with telomere shorteningbut with a number of diseases that are more common in later years.

Other factors that decrease telomere length are stress, depression, and certain gene mutations, such as that which leads to progeria — a rare condition in which children age extremely rapidly and rarely live past their teenage years.

“Recent studies have suggested that telomere length alone may not be a reliable predictor of lifespan or aging. For example, some individuals with shorter telomeres have been found to live longer than those with longer telomeres. Other factors, such as lifestyle, environment, genetics, and stress also play a role in aging and disease.”

– Dr. Joshua Berkowitz, medical director at IV Boost UK

Shorter telomeres may be associated with shorter lifespans and more rapid biological aging, but are longer telomeres therefore associated with longer lifespans and healthier aging? The evidence is not conclusive.

Many lifestyle factors that are associated with better health are also associated with telomere length.

A diet rich in legumes, whole grains, and fresh fruit and vegetables, such as the Mediterranean diet, is positively associated with telomere length in several studies. The positive effects of the Mediterranean diet on telomeres may be due to it antioxidant and anti-inflammatory properties.

Physical activity is advisable for general health, but the evidence for the effect of physical activity on telomere length is not clear-cut — although exercise is thought to be beneficial, the optimal dose of exercise is unclear.

One study found that moderate exercise helps maintain telomere length, but the benefits decrease with excessive exercise; others found an effect only in people taking extreme amounts of exercisesuch as ultra-marathon runners.

Other studies have shown that getting enough sleep, never having smoked tobacco, and avoiding stress may help preserve telomere length.

“While previous research has suggested that longer telomeres may be associated with longevity, most of this research has been done in cells, and it is not yet clear whether longer telomeres in humans are a cause or a consequence of healthy aging.”

— Sebnem Unluisler

One study even found that telomeres at both extremes — much longer or shorter than average — were associated with susceptibility to diseases. Short telomeres were linked to organ failure, and long ones to a variety of cancers.

Now, a new study has shown that longer telomeres may not be the key to healthy aging. It suggests, instead, that long telomeres allow cells with age-related mutations to live longer, increasing the likelihood of tumors and other chronic health conditions.

The study, which looked at people with a mutation (POTS1) that causes longer telomeres, found that, while some showed signs of youthfulness, such as no gray hair in their 70s, those with the mutation had a higher incidence of benign and cancerous tumors, as well as the age-related blood condition clonal hematopoiesiswhich increases the risk of several cancers, than those without.

One of the authors, Dr. Mary Armanios, professor of oncology at the Johns Hopkins Kimmel Cancer Center, and professor of genetic medicine, molecular biology and genetics, and pathology at the Johns Hopkins University School of Medicine, suggests an explanation.

According to her,[c]cells with very long telomeres accumulate mutations and appear to promote tumors and other types of growths that would otherwise be put in check by normal telomere shortening processes.”

Sebnem Unluisler commented that “[t]his study suggests that there may not be a simple relationship between telomere length and aging.”

While longer telomeres may be associated with increased cancer risk, they may also be associated with decreased risk of other age-related diseases and improved overall health,” she noted.

Telomere length is just one aspect of aging and longevity, and research is investigating many other possible factors.

“The genetic basis of aging is complex, and it is likely that both cellular and whole organism factors contribute to the aging process. While telomeres are one important factor, other genetic and epigenetic factors may also play a role in determining how quickly a person ages.”

– Sebnem Unluisler

Dr. Berkowitz agreed that there are many routes for further study. He suggested that future research might include focus on.

“Identifying genetic and epigenetic factors that contribute to aging and longevity, […] understanding the role of the microbiome in aging and longevity, and […] investigating the role of senescent cells in aging and age-related diseases,” he told us.

Although longer telomeres are associated with longevity in cells, the evidence is not conclusive that they are the key to longer, healthier lives. However, many of the lifestyle factors that reduce the risk of disease also result in longer telomeres.

the National Institutes of Health (NIH) advises the following to promote healthy aging:

  • get moving — according to one studytaking around 8,000 steps a day reduced mortality from any cause by 51% compared to taking 4,000 steps.
  • eat a healthy diet, such as the Mediterranean diet, with plenty of fresh fruit and vegetables
  • maintain a healthy weight — exercise and a healthy diet will help with this
  • get a good night’s sleep
  • do not smoke, or stop smoking if you are a smoker
  • limit your alcohol intake
  • get regular health checks
  • look after your mental health by socializing and managing stress levels.

Dr. Berkowitz echoed this advice: “While genetics play a role in determining lifespan, environmental and lifestyle factors also significantly influence an individual’s health and longevity. By making healthy choices and adopting a healthy lifestyle, individuals can reduce their risk of age-related diseases and improve their chances of living a long and healthy life.”

Longer telomeres may have some influence on your lifespan, but it is a factor you cannot control, and the evidence for their benefits is not conclusive. However, a healthy diet and lifestyle can increase lifespan and reduce the likelihood of disease even in those with a genetic predisposition.

While research into what is going on in our cells can give us pointers, the tools for healthy aging are mostly in our own hands.

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